MULTIFUNCTIONAL NANO–BIO MATERIALS WITHIN CELLULAR MACHINERY

Select: Manipulating Cellular Machinery

Taxol (paclitaxel) is a potent anticancer therapeutic typically used to treat breast, lung, and ovarian cancers. Historically it has been produced by synthetic or semisynthetic routes, requiring as many as 51 synthesis steps or the use of a plant-derived intermediate, baccatin III, respectively. Ajikumar et al. (2010) introduce a new approach to produce Taxol: engineering the isoprenoid pathway...

Multifunctional periodic cellular metals.

Periodic cellular metals with honeycomb and corrugated topologies are widely used for the cores of light weight sandwich panel structures. Honeycombs have closed cell pores and are well suited for thermal protection while also providing efficient load support. Corrugated core structures provide less efficient and highly anisotropic load support, but enable cross flow heat exchange opportunities...

The Mechanics of Multifunctional Materials

Nano-structured NiTi instantaneously transforms from fcc austenite via an intermediate phase (the R-phase) into monoclinic B19’ martensite. At a grain size less than a critical limit of about 50nm no transformation can be observed even upon cooling down to cryogenic temperatures. In slightly larger grains the martensite appears as a laminate of alternating twinrelated Bain correspondence varian...

Computational design of multifunctional materials

We propose a general scheme for the computational design of new materials using density functional theory. We then apply the scheme to two classes of materials; ferromagnetic ferroelectrics and half-metallic antiferromagnets. Our first ‘‘designer’’ ferromagnetic ferroelectric has subsequently been synthesized and the predicted properties verified. Our computations on halfmetallic antiferromagne...

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